Cancer, Reproductive, Cardiovascular and Other Chronic Disease Prevention

Picture1 Large-Scale Agricultural Industry, Women Workers, and the Implications for Child Development: The Case of the Ecuadorian Flower Industry
Alexis Handal, PhD, MPH, University of New Mexico
Industrial agriculture is an increasingly important component of the economies of developing countries and women of reproductive age have become an integral part of the labor force. The Ecuadorian cut‐flower industry is a key example and provides an opportunity to evaluate the occupational, environmental and social impacts of large‐scale agricultural production on nearby communities and workers.

Picture1 The Exposome: Implications for Occupational Health
Gayle DeBord, PhD, National Institute for Occupational Safety and Health
The exposome has been defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to disease causation. It provides an opportunity for occupational health researchers to expand exposure assessment to identify underlying causes of work‐related diseases and is likely to prove more valuable than the genome alone for understanding occupational health.

Picture1 Gender Differences in Response to Occupational Pesticide Exposures
Jane Hoppin, ScD, North Carolina State University
Pesticides may have endocrine effects which may impact men and women differently. The Agricultural Health Study, a large cohort study of both farmers and their spouses, provides the opportunity to evaluate the potential health effects of occupational exposures to pesticides in both men and women. This seminar will focus on differences in pesticide use by men and women as well as health outcomes associated with personal pesticide use including reproductive cancers, thyroid disease, and diabetes.

          Approaches to Exposure Assessment for Manganese Among Welders
          Noah Seixas, PhD, University of Washington
          Assessing exposure to manganese as a component of welding fume presents a number of challenges, and although accurate exposure biomarkers are needed, they have thus far proved elusive. This seminar will examine the literature relating air exposure to manganese (aMn) and its appearance in blood (bMn) for evidence of a quantitative relationship, and to identify limitations in these data. A study of exposure and biomarkers among welding school students is also described.

          Low Dose Environmental Chemicals and Fetal Health
          Larissa Takser, MD, PHD, Université de Sherbrooke
          Adequate protection of the developing child from environmental hazards is a public health priority. The general objective of this research is to detect subtle toxic effects at low doses of environmental exposures in utero, by integrating knowledge obtained from experimental research. This talk will explain the state of knowledge on low-dose toxicity of flame retardants, research challenges, and some aspects of decision making process related to fetal health.

          Epigenetics as the Underlying Mechanism of Developmental Basis of Disease
          Shuk-Mei Ho, PHD, University of Cincinnati
          Traditionally, genetic mutations/alterations are believed to dysregulate normal physiological functions, leading to disease development. We now know that epigenetics represents a new frontier in studying, diagnosing and treating human diseases as epigenetic changes are reversible, heritable modifications that do not involve alterations in the primary DNA sequence. This presentation will present recent data in support of a significant contribution of epigenetics in early origin of adult disease.