Development and Validation of a Neutron Activation Analysis System to quantify Aluminum in Human Bone in vivo

Research Trainee: Patrick Byrne, Graduate Student, School of Health Sciences at Purdue University

Faculty Researcher: Linda Nie, Assistant Professor, School of Health Sciences at Purdue University

Neutron activation analysis system with moderator/reflector/shielding.

The goal of this project was to develop a transportable system to quantify aluminum (Al) in bone in vivo. This will be the most accurate way to estimate the Al exposure for an individual. It is important to assess Al exposure because Al is associated with various adverse health effects especially neurological effects. Our research showed that it is feasible to develop such a system and we have already set up such a system in our lab. Our next steps are to further optimize the system and conduct a pilot human study to test the system for Al exposure assessment in a small population. Our long term goal is to use the system to investigate health effects of exposure to metal mixtures.

Project Abstract

Publications resulting from this project:
Liu Y, Mostafaei F, Sowers D, Hsieh M, Zheng W, Nie LH*. Customized Compact Neutron Activation Analysis System to Quantify Manganese (Mn) in Bone In Vivo. Physiological Measurement, 38(2017)452-465

Byrne P, Mostafaei F, Liu Y, Koltick D, Zheng W, Nie LH*. The Study of In Vivo Quantification of Aluminum (Al) in Human Bone with a Compact DD Generator-based Neutron Activation Analysis (NAA) System. Physiological Measurements, 37(2016)649-660

Grants resulting from this project:
NIOSH/CDC. 1R21OH010044-01A2 (PI: Nie). Development and Validation of a Novel In Vivo Neutron Activation. 8/1/2012-7/31/2015.

NIOSH/CDC. 5R21OH010700-02 (PI: Nie). Bone Manganese as a Biomarker for Early Diagnosis of Manganese neurotoxicity in Occupationally Exposed Workers. 9/01/2014 – 8/31/2017.