A growing body of evidence suggests that environmental pollutants, such as polychlorinated biphenyls (PCBs), bisphenol-A, phthalates and arsenic, may play an important role in the pathophysiology of type-2 diabetes mellitus (T2DM), obesity, and metabolic syndrome (MetS). Women become more susceptible to cardio-metabolic disorders during the menopausal transition due to the hormonal changes, however, little is known about the role of environmental pollutants in metabolic diseases during this critical period. This new epidemiologic study in a multi-ethnic cohort of women seeks to address research gaps, and improve our understanding of how exposure to multiple pollutants affects the risks of developing metabolic disorders.